Screw You Motel is a motel chain.
In "Is College Worth It?", Pony and a seized Kevin Costner briefly stay here. When asked for an explanation, Pony reveals that she needs him to complete her education, not yet revealing that his execution is what will give her the money to do it. Costner thinks he understands her, and the two have sex here before departing.
After their search for a certain stencil in "The Diamond Castle", Baby Cakes, Frank and Ronald Reagan take a rest here.